As with all medications, inform your prescribing doctor about any medical conditions you have and any medications and supplements you are currently taking before starting treatment with fluticasone. This drug can interact with other medicines and substances, leading to potentially serious side effects.
You should tell your provider if you are taking:
CYP3A4 Inhibitors: Drugs that inhibit the enzyme CYP3A4, such as ketoconazole and ritonavir, can increase the levels of fluticasone in the body, potentially leading to a higher risk of side effects.
CYP3A4 Inducers: Medications that induce CYP3A4, like rifampin and certain anticonvulsants, may reduce the effectiveness of fluticasone by increasing its metabolism and decreasing its levels in the body.
Other Corticosteroids: Concurrent use of other corticosteroid medications, whether inhaled or systemic (oral or injectable), can increase the risk of corticosteroid-related side effects.
Beta-Blockers: Non-selective beta-blockers like propranolol may lead to bronchospasm or worsen asthma symptoms in some individuals when used with fluticasone. Like those primarily targeting beta-1 receptors, selective beta-blockers may have a lower risk of such interactions.
Antifungal Medications: Some antifungal drugs, like itraconazole and ketoconazole, can interact with fluticasone and increase its concentration in the body, potentially leading to more side effects.
HIV Protease Inhibitors: Certain HIV protease inhibitors, such as ritonavir, may increase the levels of fluticasone and its side effects.
Monoamine Oxidase Inhibitors (MAOIs): MAOIs can interact with fluticasone and increase the risk of side effects, including increased blood pressure.
This is not a complete list of all drugs that interact with levocetirizine. Make a comprehensive list of all medicines and supplements that you take before starting treatment with this drug.
You should also tell your health care provider about any medical conditions you manage.
Let your doctor know if you are pregnant or plan on becoming pregnant before starting treatment with fluticasone. If you become pregnant while taking this medication, stop taking it and inform your health care provider immediately.