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Guanfacine ER

Common Brand Names: Intuniv

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 21, 2025

Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

Quick Facts:

  • Brand Name: Intuniv
  • Generic Name: Guanfacine ER
  • Uses: Treatment for ADHD and hypertension
  • Drug Class: Alpha-2 adrenergic agonist
  • Availability: Prescription only
  • Generic Status: Yes
  • Controlled Substance: No

What is extended-release guanfacine?

Extended-release guanfacine is a prescription medication used to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents.

What is extended-release guanfacine used to treat?

Extended-release guanfacine is prescribed for the treatment of ADHD as part of a comprehensive treatment plan that may include other therapies, such as behavioral therapy.

How does extended-release guanfacine work?

Guanfacine belongs to a class of medications known as alpha-2 adrenergic agonists. It works by stimulating certain receptors in the brain, which helps to improve attention, impulse control, and behavior in individuals with ADHD.

How do I take extended-release guanfacine?

Guanfacine is available as an oral tablet or extended-release tablet. It can usually be taken with or without food.

Do not take extended-release guanfacine with high-fat meals.

Follow your healthcare provider's instructions regarding the dosage and administration of guanfacine.

How long until I see results?

Extended-release guanfacine (ER) is used to manage ADHD. The time it takes to notice the effects of extended-release guanfacine may vary depending on the individual and the condition being treated. Improvement in ADHD symptoms may be noticed within a few weeks of starting treatment. Continue using extended-release guanfacine as prescribed, even if you start feeling better. Regular use according to your prescription is crucial for managing your condition.

Are there any other uses for extended-release guanfacine?

While extended-release guanfacine is primarily used for treating ADHD in children and adolescents, healthcare providers may prescribe it off-label for other conditions. Discuss any alternative uses of guanfacine with your healthcare provider.

Dosage forms of extended-release guanfacine

Extended-release guanfacine is available in the following dosage forms:

  • Oral tablets

Extended-release guanfacine is a prescription medication. You must have a valid prescription from a licensed healthcare provider to obtain it.

Side Effects and Precautions for Guanfacine Extended-Release


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What are the side effects of extended-release guanfacine?

The use of extended-release guanfacine can lead to various side effects in some individuals.

Common mild side effects of extended-release guanfacine use include:

  • Drowsiness
  • Fatigue or weakness
  • Irritability
  • Headache
  • Dizziness
  • Dry mouth
  • Constipation
  • Stomach pain
  • Decreased appetite
  • Decreased libido
  • Insomnia

More severe side effects include:

  • Hypotension (low blood pressure)
  • Bradycardia (slow heart rate)
  • Fainting
  • Mood changes or depression
  • Severe allergic reactions (rash, itching, swelling)

If you experience any severe or concerning side effects while taking extended-release guanfacine, contact your healthcare provider right away.

What should I tell my healthcare provider before using extended-release guanfacine?

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with extended-release guanfacine. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with guanfacine.

Tell your provider if you are taking these medications or supplements:

  • Other ADHD medications
  • Antihistamines
  • Blood pressure medications
  • Heart medications
  • Sedatives or tranquilizers
  • Antidepressants
  • Anti-anxiety medication
  • Certain seizure medications
  • HIV medication
  • Opioid pain medications
  • Antibiotics
  • Antifungals
  • Cyclosporine
  • Tizanidine

You should also mention medical conditions such as:

  • Heart problems
  • Liver or kidney disease
  • Low blood pressure
  • Recent stroke or heart attack
  • Recent or upcoming surgery (including dental surgery)
  • History of fainting
  • Liver or kidney disease

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using guanfacine with your healthcare provider.

Are there any other special instructions I should follow?

Take extended-release guanfacine exactly as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment.

Extended-release guanfacine can cause drowsiness or dizziness. Do not drive or operate machinery until you know how this medication affects you.

Complete the full course of treatment, even if you feel better, to ensure the medication's effectiveness in managing your condition.

What should I do in case of an overdose?

In case of an extended-release guanfacine overdose, seek medical attention immediately. Symptoms of overdose may include severe drowsiness, dizziness, slow heart rate, and low blood pressure. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Guanfacine Extended-Release


Drug Information | Side Effects | Use & Dosage | Request an Online Prescription

What is the typical starting dose for extended-release guanfacine?

Extended-release guanfacine is available in the following form:

  • Oral tablets (1 mg, 2 mg, 3 mg, 4 mg)

The typical starting dose of extended-release guanfacine varies depending on the condition being treated, the severity of symptoms, and individual patient factors. It is crucial to follow your healthcare provider's instructions regarding dosage and administration.

For ADHD:

  • Children and adolescents: The typical starting dose is 1 mg once daily (taken in the morning or the evening)

The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.

Extended-release guanfacine should be taken as prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.

If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.

What should I do if I miss a dose of extended-release guanfacine?

If you miss a dose of extended-release guanfacine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Take extended-release guanfacine around the same time every day to maintain a consistent amount of medication in your body.

What should I do if I'm feeling better while taking extended-release guanfacine?

Continue taking extended-release guanfacine as prescribed by your healthcare provider, even if you start feeling better. It's important to keep taking the medication as directed to manage your condition effectively.

Do not suddenly stop taking extended-release guanfacine; this can cause a return of your symptoms. It can also cause side effects by suddenly stopping the medication. Your doctor will slowly lower your dose if you need to stop taking it.

If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.

How should I store extended-release guanfacine?

Store extended-release guanfacine according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.

Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.

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