Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/20/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

• Brand Name: Zoloft
  
• Generic Name: Sertraline
  
• Uses: Depression, anxiety disorders, OCD, PTSD, PMDD
  
• Drug Class: Selective serotonin reuptake inhibitor (SSRI)
  
• Availability: Prescription only
  
• Generic Status: Yes
  
• Controlled Substance: No
  
  

Sertraline is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). It works by restoring the balance of serotonin, a neurotransmitter in the brain.

Sertraline is used to treat conditions such as:

• Major depressive disorder (MDD)
  
• Generalized anxiety disorder (GAD)
  
• Panic disorder
  
• Social anxiety disorder (SAD)
  
• OCD (obsessive-compulsive disorder)
  
• PTSD (post-traumatic stress disorder)
  
• PMDD (premenstrual dysphoric disorder)
  
  

It may also be prescribed for other mental health conditions as determined by your healthcare provider.

Sertraline works by increasing the levels of serotonin in the brain, which helps improve mood, sleep, appetite, and energy levels.

Sertraline is usually taken orally, once daily, with or without food, as directed by your healthcare provider. The dosage and duration of sertraline treatment depend on your condition and response to the medication.

Follow the prescribed dosage and schedule strictly. Do not stop taking sertraline suddenly without consulting your healthcare provider, as it may cause withdrawal symptoms.

The time it takes to feel the full effects of sertraline can vary from person to person. Some people may notice improvement in their symptoms within a few weeks, while others may require several weeks of treatment.

It's important to continue taking sertraline as prescribed even if you do not feel better immediately. Talk to your healthcare provider if you have any concerns about your treatment.

While sertraline is primarily used for depression and anxiety disorders, healthcare providers may sometimes prescribe it off-label for other conditions, such as:

• Sexual problems
  
• Binge-eating disorder
  
• Menopause symptom treatment
  
  

Discuss any alternative uses of sertraline with your healthcare provider.

Sertraline is available in the following dosage forms:

• Oral tablets: Available in various strengths (e.g., 25mg, 50mg, 100mg)
  
• Oral concentrate solution
  
  

Generic versions of sertraline are available under various brand names.

Sertraline is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this antidepressant.