Medically reviewed by Jessica Swirble, PharmD
Last updated on April 2, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Sertraline is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). It works by restoring the balance of serotonin, a neurotransmitter in the brain.
Sertraline is used to treat conditions such as:
It may also be prescribed for other mental health conditions as determined by your healthcare provider.
Sertraline works by increasing the levels of serotonin in the brain, which helps improve mood, sleep, appetite, and energy levels.
Sertraline is usually taken orally, once daily, with or without food, as directed by your healthcare provider. The dosage and duration of sertraline treatment depend on your condition and response to the medication.
Follow the prescribed dosage and schedule strictly. Do not stop taking sertraline suddenly without consulting your healthcare provider, as it may cause withdrawal symptoms.
The time it takes to feel the full effects of sertraline can vary from person to person. Some people may notice improvement in their symptoms within a few weeks, while others may require several weeks of treatment.
It's important to continue taking sertraline as prescribed even if you do not feel better immediately. Talk to your healthcare provider if you have any concerns about your treatment.
While sertraline is primarily used for depression and anxiety disorders, healthcare providers may sometimes prescribe it off-label for other conditions, such as:
Discuss any alternative uses of sertraline with your healthcare provider.
Sertraline is available in the following dosage forms:
Generic versions of sertraline are available under various brand names.
Sertraline is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this antidepressant.
The use of sertraline can lead to various side effects in some individuals.
Common mild side effects of sertraline use include:
More severe side effects of sertraline use can include:
If you experience any severe side effects while taking sertraline, seek immediate medical attention.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with sertraline. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with sertraline.
Tell your provider if you are taking these medications or supplements:
Mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using sertraline to assess potential risks and benefits.
Take sertraline exactly as prescribed by your healthcare provider. Do not increase or decrease the dosage without consulting them.
It may take several weeks for sertraline to take full effect. Continue taking the medication even if you do not immediately feel better.
Avoid alcohol while taking sertraline, as it may worsen certain side effects.
Do not suddenly stop taking sertraline without your healthcare provider's guidance, as it may cause withdrawal symptoms.
In case of a sertraline overdose, seek immediate medical attention. Symptoms may include severe dizziness, drowsiness, nausea, vomiting, rapid heartbeat, tremors, seizures, and coma. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Sertraline is available in various strengths, including:
The typical starting dose of sertraline for depression, anxiety disorders, and other mental health conditions can vary depending on factors such as the specific condition being treated, your age, other medical conditions, and how you respond to the medication. It's crucial to follow your healthcare provider's instructions regarding dosage and administration carefully.
For most adults with depression or anxiety disorders, the typical starting dose of sertraline may be:
However, your healthcare provider may start with a lower dose, such as 25 mg, especially for older adults or those with certain medical conditions. The dose may then be gradually increased based on your response and tolerability, up to a maximum of 200 mg per day.
Sertraline should be taken with or without food, but it's important to take it consistently at the same time each day.
Your healthcare provider will monitor your response to sertraline and may adjust the dose as needed. It's important not to exceed the recommended dose or make changes to your dosage without consulting your healthcare provider.
If you have any questions about your dosage or how to take sertraline, contact your healthcare provider or pharmacist. If you want to talk to a provider right away, consider booking an online doctor appointment on Sesame to discuss your concerns.
If you miss a dose of sertraline, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose of sertraline to make up for a missed one.
Continue taking sertraline as prescribed by your healthcare provider, even if you start feeling better. Abruptly stopping sertraline can lead to withdrawal symptoms and potential relapse of symptoms. Follow your provider's instructions regarding the duration of treatment.
Store sertraline according to the instructions provided by your healthcare provider or pharmacist. It should be kept at room temperature, away from excessive heat, light, and moisture. Ensure the container is tightly closed and keep the medication out of the reach of children.