Before using vilazodone, inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with vilazodone.
Vilazodone should not be used within 14 days of discontinuing an MAOI (monoamine oxidase inhibitor) medication or within 14 days of starting an MAOI. Serious and potentially life-threatening reactions can occur when MAOIs are combined with vilazodone.
You should also tell your healthcare provider if you are taking:
Serotonergic Medications: Combining vilazodone with other serotonergic drugs, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or triptans, may increase the risk of serotonin syndrome, a potentially serious condition characterized by symptoms such as agitation, hallucinations, rapid heart rate, fever, and muscle stiffness.
Strong CYP3A4 Inhibitors: Medications that strongly inhibit the CYP3A4 enzyme, such as ketoconazole, may increase the levels of vilazodone in the bloodstream, potentially leading to increased side effects.
CYP3A4 Inducers: Drugs that induce CYP3A4, such as rifampin, may reduce the effectiveness of vilazodone by increasing its metabolism and decreasing its levels in the body.
Alcohol: Combining alcohol with vilazodone may increase the risk of central nervous system depression and impaired cognitive and motor skills. It's advisable to limit or avoid alcohol consumption while taking vilazodone.
Digoxin: Digoxin has a narrow therapeutic range, which can be increased by vilazodone.
Antiplatelet/anticoagulant Medications: Combining these medications with vilazodone can increase your risk of bleeding.
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using vilazodone to weigh the potential risks and benefits.