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6 Ways to Get Rid of Cold Sores Fast
April 28, 2023
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Read Time - 5 minutes
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Last updated on March 18, 2024

Understanding your best treatment options for a cold sore outbreak

Cold sores—also known as oral herpes or fever blisters—are small, fluid-filled blisters that appear on or around the lips. They are caused by the herpes simplex virus type 1 (HSV-1), which spreads through skin-to-skin contact or saliva exposure.

Unfortunately, once you have this viral infection, you carry it for life. The virus will stay dormant for weeks or months and only reappear during an outbreak or flare-up. Although cold sores cannot be cured, several treatment options are available to reduce your symptoms and speed up the healing process.

6 Ways to Get Rid of Cold Sores Fast


Medicated Treatment for Cold Sores

While nothing can cure a cold sore overnight, various effective medication options are available to help reduce painful symptoms and speed up the healing process.

1) Prescription antiviral drugs

Prescription antiviral medication is the most effective and efficient way to clear up a cold sore fast. Antiviral cold sore treatment will start to work right away. Most people experience a reduction of symptoms within 2-3 days of starting treatment. Cold sores will go away about one day sooner when you use prescription antiviral medication.

These drugs may be prescribed as an oral medication or topical cream applied directly to the sores. FDA-approved antiviral cold sore medication includes:

Antiviral medication works best if you start treatment at the first sign of a cold sore outbreak. Telemedicine can help with this. With the advent of telemedicine, you can talk to a licensed healthcare provider within the same day your symptoms appear. They can prescribe medication to pick up at your local pharmacy, usually within a few hours of your appointment.

2) Over-the-counter medications

Although over-the-counter (OTC) treatment options aren’t as effective as prescription medication, they can help reduce symptoms and speed up healing time.

Common OTC treatment options include:

  1. Docosanol (generic for Abreva): Docosanol is an antiviral medication. It is available as a lip balm or medicated gel. Take docosanol as soon as you begin to notice symptoms. It will heal lesions within 2-4 days.

  2. Lidocaine and benzocaine (generic for Orajel): Lidocaine and benzocaine are OTC pain relievers that help soothe pain caused by cold sore lesions. They are available as lip balm or medicated liquids that can be applied to sores with an applicator. You will instantly experience pain relief, although the sore may take several days to heal completely.

Follow the packaging’s instructions when applying topical medication. Avoid touching the sore directly. Do not use more than the recommended amount of OTC medication, as this may cause side effects.

3) Over-the-counter pain relievers

While OTC pain relievers will not speed up recovery time, they can help reduce the pain and discomfort caused by cold sores. OTC pain relievers start to work within 30 minutes of being taken.

Common OTC pain relievers include:

  • Acetaminophen (generic Tylenol)
  • Ibuprofen (generic Advil)

If you are taking a prescription antiviral medication, talk to a healthcare provider about whether or not it is safe to supplement that treatment with OTC pain medication.

You should seek medical advice from a healthcare provider before using OTC medication to treat cold sores. Speaking to a healthcare provider can help you learn more about potential side effects and any precautions to be aware of.

Home remedies for cold sores

Medication, especially prescription antivirals, is the most effective form of treatment. However, at-home cold sore remedies can reduce symptoms and speed healing.

4) Cold compress

Apply a cold compress or ice to the affected area to numb the painful burning sensation. This remedy can also reduce some of the redness and inflammation caused by sores. Wrap the ice in a clean, damp rag and hold it to the sore for 10 minutes. Do this 3 times a day. Do not use cold compresses for longer than 15 minutes, which can cause skin irritation. Do not apply ice directly to the skin, as this can irritate it. Cold compresses will soothe cold sore pain immediately and numb the area. However, this effect will wear off.

5) Propolis

Propolis is a resin-like substance made by honey bees from the buds of poplar or cone-bearing trees. This extract has antiviral properties that can reduce symptoms and help a cold sore heal. Propolis is available in creams, ointments, and gels. Studies show that propolis can heal sores in 8 days, while acyclovir can take up to 9 days to heal a sore fully. However, some people have found that propolis irritates their skin further. If you begin to notice any side effects of propolis use, stop applying it and speak to a healthcare provider.

6) Lemon balm

Confusingly, lemon balm is actually an herb in the mint family. Lemon balm essential oils contain antioxidants that may combat the herpes virus. Applying lemon balm gel or essential oil to an outbreak can help soothe symptoms and encourage healing. More research is needed to fully determine how effective lemon balm is as a cold sore treatment.

Cold Sore Prevention


Once infected with the herpes simplex 1 virus (HSV-1), you will carry it for the rest of your life. While the underlying cause of cold sores cannot be cured, you can use preventative measures to help reduce the risk of an outbreak.

To help prevent and manage outbreaks, doctors often recommend the following:

  1. Moisturize: Use lip balms and creams to keep lips moisturized. This will also prevent scabs from cracking and spreading the outbreak.

  2. Protect your lips: Use a zinc oxide cream or a sunscreen lip balm with SPF to protect your lips from the sun. This will prevent drying and cracking.

  3. Take lysine supplements: Oral lysine supplements or topical lysine creams have been shown to prevent outbreaks and speed up the healing time of outbreaks.

  4. Avoid oral sex: This is especially important during active outbreaks. Kissing and skin contact are among the most common forms of HSV-1 transmission. Additionally, engaging in oral sex or kissing with an existing outbreak can irritate the affected area. If you are currently experiencing a blister, wait until the sore has gone away before you kiss or engage in oral sex.

  5. Avoid sharing: The HSV-1 virus spreads through contact and saliva exposure. Avoid sharing lip balms, toothbrushes, and other products that may come into contact with sores. If you experience an outbreak, disinfect or replace these items after your symptoms subside.

  6. De-stress: Stress can affect your immune system, triggering a flare-up of cold sore symptoms. Try deep breathing exercises and meditation to help manage your stress. This can help reduce your risk of triggering an outbreak while also positively impacting your overall wellness.

How Sesame can help

At Sesame, you can get cold sore help fast with same-day online cold sore treatment. These convenient and affordable appointments will connect you to a provider right away to discuss treatment options and ways to soothe an outbreak.


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Medical disclaimer

Sesame content is not intended to be a substitute for professional medical advice, diagnosis or treatment. If you have a medical concern, it is critical to seek the advice of your physician or another qualified health provider with any questions. If you are facing a medical emergency, call 911 or visit the nearest emergency room immediately.