Buy acyclovir (generic Zovirax) prescriptions and medications online for cold sores

Get a same-day acyclovir (generic Zovirax) online prescription today. Pick up at your local pharmacy or choose $5 home delivery. FDA-approved prescription relief for your cold sores has never been easier or more affordable.

Local same-day pharmacy pick up
$5 home delivery (including cost of medication)
Prescription available at provider's discretion
95% patient satisfaction
$25,000,000+ saved by patients
4.3 on
Trustpilot logo
Named Best Overall Telehealth byHealthline logo
As someone without insurance, Sesame was really great. – Dominic

See a doctor today to get a new prescription or refill for just $5 with free delivery

Product Overview

Acyclovir (generic Zovirax)

  • What is acyclovir?
    Acyclovir (generic Zovirax) is an antiviral medication primarily used to treat cold sores (herpes simplex). It is also effective in treating shingles (herpes zoster), varicella (chickenpox), and genital herpes. Acyclovir works by targeting herpes simplex, the virus that causes cold sores. Even after a cold sore outbreak has dissipated, the herpes simplex continues to live in your body - leaving you at risk of future outbreaks. As an antiviral drug, acyclovir targets herpes simplex to reduce the cadence and severity of these outbreaks - keeping you healthy and your cold sores to a minimum.

    Looking for a safe, effective way to manage symptoms of herpes? Talk to your doctor about whether acyclovir is right for you.

  • What are common side effects of acyclovir?
    While adverse reactions to acyclovir are uncommon, some patients who take the drug may experience mild side effects, including malaise, nausea, vomiting, diarrhea, abdominal pain, and headache.

    Dizziness, kidney problems, mood changes, trouble speaking, and unsteady movement rarely occur, but have been known to be serious side effects of acyclovir. If you are experiencing any of these conditions, call your doctor right away.

    This is not a complete list of side effects. For more information on adverse reactions you may experience while taking acyclovir, contact your doctor directly.

How SesameRx Works

Did you know the price of prescription medication can vary? With Sesame, you always get the best price.

1. Book a Visit
Talk to a doctor about your condition and get a prescription for allergies, anxiety, birth control, erectile dysfunction, depression, diabetes, and more.
2. Get a Prescription
Book a visit with a doctor on Sesame to get access to $5 medication. After your doctor writes your prescription, we’ll send you a link to pay for your medication.
3. Sit Back & Save
We’ll send your prescription directly to your door and automatically refill your medication at the same affordable price.
Book a visit
Simple & Affordable

Why patients trust SesameRx.

  • FDA-approved medication
    Hundreds of generic medications starting at $5 delivered right to your door.

  • Free & fast delivery
    Easy tracking to check the status of your prescription.

  • Dedicated customer support
    SesameRx's dedicated English and Spanish-language support available to help whenever you need.

Patients Love SesameRx
Medically Reviewed By Dr. Allison Edwards, MD

Frequently asked questions about acyclovir

What is acyclovir?

Acyclovir (generic Zovirax) is an antiviral medication primarily used to treat cold sores (herpes simplex). It is also effective in treating shingles (herpes zoster), varicella (chickenpox), and genital herpes. Acyclovir is prescribed to more than 4 million Americans each year and can be taken orally, topically, or via injection.

Acyclovir works by targeting herpes simplex, the virus that causes cold sores. Even after a cold sore outbreak has dissipated, herpes simplex continues to live in your body - leaving you at risk of future outbreaks. As an antiviral drug, acyclovir targets herpes simplex to reduce the cadence and severity of these outbreaks - keeping you healthy and your cold sores to a minimum.

What is acyclovir used to treat?

The U.S. Food and Drug Administration has approved acyclovir to treat cold sores (herpes simplex), varicella (chickenpox), shingles (herpes zoster), and genital herpes.

How does acyclovir work?

Acyclovir belongs to a group of antiviral drugs. These medications work by targeting viruses within the body and inhibiting their development. They identify and disarm key proteins within the virus, helping limit the infection and ease your symptoms. Antivirals are used to treat a range of conditions, including herpes, HIV, hepatitis, and even COVID-19.

It should be noted that acyclovir does not cure herpes. After infection, the herpes simplex never fully leaves your body. While it can remain dormant for long periods of time, it will be with you for the rest of your life. Acyclovir, though, can significantly reduce the likelihood and frequency of cold sore and herpes outbreaks and help ensure that - when cold sores do strike - they are less severe than would be without treatment.

What are the most common side effects of acyclovir?

Common side effects of acyclovir can include malaise, nausea, vomiting, diarrhea, abdominal pain, and headache.

Dizziness, kidney problems, mood changes, trouble speaking, and unsteady movement are all rare but serious side effects of acyclovir. If you are experiencing any of these conditions, call your doctor right away.

How long does it take for acyclovir to work?

You can expect to feel symptom relief after about 3 days of taking acyclovir. If you’ve been prescribed acyclovir for chickenpox, symptoms usually begin to dissipate within 48 hours.

What’s a typical starting dose of acyclovir?

If you’ve been prescribed oral doses of acyclovir for genital herpes, it is recommended you take 200 mg 5 times per day for 10 days. To treat recurrent herpes outbreaks, acyclovir may be prescribed 5 times per day for up to a year. For chickenpox, adults and children over 88 pounds should take 800 mg of acyclovir four times per day for five days. Shingles patients are often prescribed 800 mg of acyclovir 5 times per day for 7-10 days.

Can I get acyclovir over-the-counter?

Acyclovir is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Looking for a prescription? Good news! Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you or order the medication to be delivered to your door for just $5. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not acyclovir is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Can I get acyclovir online?

Yes! Sesame offers a fully integrated prescription service, which means you can get the medication you need delivered right to your door, starting at just $5 a month.

Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.