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Acetaminophen

Common Brand Names: Tylenol

Drug Information

Medically reviewed by Jessica Swirble, PharmD
Last updated on April 18, 2025

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Quick facts:

  • Brand Name: Tylenol
  • Generic Name: Acetaminophen
  • Uses: Treatment for pain relief and fever reduction
  • Drug Class: Analgesic (pain reliever) and antipyretic (fever reducer)
  • Availability: Over-the-counter
  • Generic Status: Yes
  • Controlled Substance: No

What is acetaminophen?

Acetaminophen is a frequently used drug that treats pain and discomfort from diverse medical conditions. It is widely available over the counter at most convenience stores, grocery stores, and medical retailers. Acetaminophen helps reduce uncomfortable symptoms caused by headaches, fevers, mild injuries, and more. It is also frequently combined with other forms of medication (such as ibuprofen or diphenhydramine).

What is acetaminophen used to treat?

Acetaminophen can be used to treat symptoms of health conditions such as:

  • Headaches
  • Fever
  • Common colds
  • Toothaches
  • Menstrual cramps
  • Pain from osteoarthritis
  • Pain from mild-to-moderate arthritis
  • Muscle aches and soreness

How does acetaminophen work?

Acetaminophen is classified as an analgesic (pain reliever) and antipyretic (fever reducer) medication. It works by blocking certain chemicals (called prostaglandins) that cause pain, and fever.

How do I take acetaminophen?

Acetaminophen is available in the following forms:

  • Oral tablets
  • Oral liquid
  • Chewable tablets
  • Dissolve packs
  • Rectal suppositories

The dosage and frequency of use depend on the condition being treated, its severity, and how you respond to the medication.

Follow your healthcare provider's instructions regarding dosage and schedule. Do not exceed the prescribed dose or frequency of use without consulting your provider.

How long until I feel better?

Acetaminophen is used to manage pain and reduce fever. The effects can be noticeable within 30 minutes to an hour after taking it.

Are there any other uses for acetaminophen?

While acetaminophen is primarily used for pain relief and fever reduction, healthcare providers may also recommend it for other conditions, such as cold symptoms and headaches.

Discuss any alternative uses of acetaminophen with your healthcare provider.

Dosage forms of acetaminophen

Acetaminophen is available in the following dosage forms:

  • Oral tablets
  • Oral liquid
  • Chewable tablets
  • Dissolve packets

Acetaminophen is available over-the-counter. You do not need a prescription from a licensed healthcare provider to obtain this medication.

Side Effects and Precautions for Acetaminophen


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What are the side effects of acetaminophen?

The use of acetaminophen can lead to various side effects in some individuals.

Common mild side effects of acetaminophen use include:

  • Nausea
  • Upset stomach
  • Vomiting
  • Loss of appetite
  • Headache
  • Dizziness or lightheadedness
  • Sweating

More severe side effects of acetaminophen use can include:

  • Skin rash
  • Swelling (mainly in the face, hands, ankles, legs, or feet)
  • Hives
  • Red, blistering, or peeling skin
  • Insomnia
  • Fatigue
  • Difficulty breathing or swallowing
  • Severe nausea and vomiting
  • Yellowing of the skin or eyes, dark urine, pain in the abdomen

If you experience any severe or concerning side effects while taking acetaminophen, contact your healthcare provider right away.

What should I tell my healthcare provider before using acetaminophen?

Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with acetaminophen. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with acetaminophen.

Tell your provider if you are taking these medications or have these conditions:

  • Other pain relievers or fever reducers
  • Blood thinning medications

You should also mention medical conditions such as:

  • Liver disease or a history of liver problems
  • Kidney disease
  • Diabetes
  • High blood pressure

People who drink more than three alcoholic drinks a day should not use acetaminophen. Acetaminophen can interact with alcohol in the body, causing potentially serious side effects. If you regularly consume alcohol, talk to a healthcare provider before you take acetaminophen.

If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using acetaminophen with your healthcare provider.

Are there any other special instructions I should follow?

Take acetaminophen exactly as directed on the package. Do not exceed the recommended dose or duration of treatment.

Acetaminophen can be taken with or without food, but taking it with food may help reduce stomach upset.

What should I do in case of an overdose?

In case of an acetaminophen overdose, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, loss of appetite, confusion, jaundice (yellowing of the skin or eyes), and severe pain in the upper stomach. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.

Proper Use & Dosage Information for Acetaminophen


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What is the typical starting dose for acetaminophen?

Acetaminophen is available in the following forms:

  • Oral tablets
  • Oral liquid
  • Chewable tablets
  • Dissolve packets

The typical starting dose of acetaminophen varies depending on the individual's age, weight, and the condition being treated. It is crucial to follow your healthcare provider's instructions or the directions on the package regarding dosage and administration.

For pain relief and fever reduction:

  • Adults: Typically, 325 to 650 mg every four to six hours as needed
  • Children: Dosage is based on body weight and must be determined by your doctor

The dosage may be adjusted based on the response and tolerance to the medication. Your healthcare provider will determine the most appropriate dose based on your medical history and your response to the medication.

Acetaminophen should be taken as directed on the package or prescribed by your healthcare provider. Do not exceed the recommended dose or duration of treatment without consulting your provider.

If you have any questions about your dosage or need adjustments, contact your healthcare provider for guidance. If you want to talk to a provider right away, consider scheduling an online doctor appointment through a telehealth platform like Sesame.

What should I do if I miss a dose of acetaminophen?

If you miss a dose of acetaminophen, take it as soon as you remember unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.

Take acetaminophen around the same time every day to maintain an even level of medication in your body.

What should I do if I'm feeling better while taking acetaminophen?

Continue taking acetaminophen as directed, even if you start feeling better. It's important to keep taking the medication as directed to ensure that your symptoms are effectively managed.

If you have any concerns or questions about your medication, discuss them with your healthcare provider for medical advice and recommendations.

How should I store acetaminophen?

Store acetaminophen according to the instructions provided by your healthcare provider or pharmacist. Keep it at room temperature, away from light and moisture. Ensure the container is tightly closed and out of reach of children.

Do not use expired medication or medications that appear damaged or discolored. If you have any questions about storage, consult your healthcare provider or pharmacist for guidance.

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