Alprostadil is commonly administered as a urethral suppository (small pellets containing the medication that are inserted into the penis via the urethra) or injection. Both methods will begin to work within 5-10 minutes after application. It is recommended that you attempt intercourse within 10-30 minutes after taking the medication.
Urethral suppository:
It is recommended that you urinate before inserting the suppository pellet. Leftover urine will help the medication dissolve. Follow your doctor’s orders as to how to insert the medication into the urethra. If you feel any pain or discomfort while administering the medication, withdraw the insertion stem from the urethra and gently try again. Be sure to double-check the delivery device to ensure that the medication was released and inserted into the penis. If you have any questions about the best method to insert the delivery device, or how to get the pellet to dissolve quickly, talk to the prescribing health care provider.
The exact dosage prescribed will depend on the patient and the severity of the condition. In general, one suppository can be inserted into the urethra 10-30 minutes before intercourse. Urethral suppositories should not be used more than once in a 24-hour period.
Do not adjust or increase your dosage without consulting with your health care provider first. Additionally, do not reuse the delivery device. Dispose of the device once it has been used.
Injection:
You will receive your first dose of an alprostadil injection in your health care provider’s office to determine the best dosage for you. After this, you will be trained by your provider as to how to inject the medication yourself. Make sure you understand exactly how to inject this medication, as well as proper storage and handling practices.
Before injecting alprostadil, you must wash your hands thoroughly with soap and warm water. Wipe the top of the injection bottles and the injection site with an alcohol swab. Do not apply the alcohol swab to the tip of the needle.
The exact dosage prescribed will depend on the patient and the severity of the condition. Take this medication 10-30 minutes before attempting sexual intercourse. Do not use this medication 2 days in a row, or more than 3 times per week.
Do not reuse or share injection needles. Dispose of injection bottles and used needles immediately after use. Follow your doctor’s instructions exactly as directed. If you experience any side effects from an injection, get in touch with a health care provider right away.
Do not increase your dosage of alprostadil without your doctor’s express orders.