Bupropion and naltrexone is primarily prescribed to help individuals manage their weight. It is intended for adults with obesity---having a body mass index BMI of 30 or higher---or for overweight individuals (BMI of 27 or higher) who are also managing a weight-related health condition, such as type 2 diabetes, high blood pressure, or high cholesterol.

This medication is most effective when used as part of a comprehensive weight loss plan that includes a reduced-calorie diet and increased physical activity.

Bupropion and naltrexone is a combination medication that addresses weight loss in several ways.

The combination of bupropion and naltrexone work together in the brain. Their synergistic effect helps reduce appetite and increase the feeling of fullness after meals. This makes it easier to control calorie intake.

In addition, these two drugs work together to reduce the rewarding effects of foods and cravings, particularly for high-calorie and high-sugar foods.

By targeting both appetite control and cravings, bupropion and naltrexone can help patients achieve sustainable weight loss when used as part of a comprehensive weight management program that includes a reduced-calorie diet and increased physical activity.

Bupropion and naltrexone may cause side effects in some individuals, although not everyone will experience them.

Mild side effects may include:

• Nausea
  
• Vomiting
  
• Headache
  
• Dizziness
  
• Fatigue
  
• Diarrhea
  
• Constipation
  
• Dry mouth
  
• Increased heart rate
  
• Trouble sleeping
  
  

More severe side effects include:

• Skin rash
  
• Hives
  
• Swelling in the lips or tongue
  
• Seizures
  
• Shortness of breath
  
• Chest pain
  
• Fever symptoms
  
• Yellowing of the skin or eyes
  
• Muscle or joint pain
  
• Dark-colored urine
  
• Suicidal thoughts or actions
  
• Depression and/or anxiety
  
  

It's important to promptly report any side effects or concerns to your healthcare provider.

Before starting bupropion and naltrexone, discuss your medical history and any existing medical conditions with your healthcare provider. It's important to disclose any allergies or other medications you are taking, including prescription drugs, over-the-counter medications, and dietary supplements, to prevent potential interactions.

Specifically, mention any history of:

• Seizures
  
• Eating disorders
  
• Mood disorders
  
• High blood pressure
  
• Diabetes
  
• Low blood sugar
  
• Alcohol or substance abuse
  
• Liver problems
  
• Kidney problems
  
• Heart disease
  
  

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using bupropion and naltrexone to assess potential risks and benefits for both you and your baby.

The recommended dosing regimen for bupropion and naltrexone may vary depending on your individual needs and your healthcare provider's guidance. It is typically taken orally in tablet form.

The standard starting dose of bupropion and naltrexone is usually one tablet in the morning, increasing gradually to the full recommended dose of two tablets in the morning and two tablets in the evening. Your healthcare provider will provide specific instructions on how to titrate the medication to reach the target dose. Do not take bupropion and naltrexone with a high-fat meal, as this can increase your risk of seizures.

Follow your healthcare provider's instructions regarding dosing and other recommendations for taking bupropion and naltrexone. Do not adjust your dose without consulting your doctor, as this can affect the medication's effectiveness.

Bupropion and naltrexone is available by prescription only. A licensed healthcare provider must authorize the use of this medication.

Looking for a prescription? Providers on Sesame can assess your eligibility and prescribe bupropion and naltrexone if it's appropriate for your medical condition and needs. Depending on the medication, you can arrange for same-day pickup at your pharmacy. Book an online consultation with a licensed provider on Sesame today to determine whether this combination medication might be right for you.

Note that all prescriptions are at the discretion of your healthcare provider. Sesame cannot guarantee that you will be provided a prescription after a video or in-person appointment.

Bupropion-naltrexone (Contrave) usually costs around $300 without insurance. If you have insurance, you can book a video weight loss program to discuss treatment options with a licensed healthcare provider. Bupropion-naltrexone can be prescribed during these appointments, if deemed appropriate by your provider. If you receive a bupropion-naltrexone prescription during your weight loss appointment, you may be eligible to have part of your visit and your medication covered by your insurance network. Our video weight loss program works with insurance to help cover the cost of your treatment.

Note that all prescriptions are at the discretion of your healthcare provider. A video weight loss appointment does not guarantee a bupropion-naltrexone prescription.