Medically reviewed by Jessica Swirble, PharmD
Last updated on April 2, 2025
Drug Information | Side Effects | Use & Dosage | Request an Online Prescription
Bupropion is an antidepressant medication that belongs to the class of drugs known as norepinephrine-dopamine reuptake inhibitors (NDRIs). It is used to treat major depressive disorder (MDD), and seasonal affective disorder (SAD). It is also used to help in smoking cessation (quitting smoking).
Bupropion is used to treat conditions such as:
It may also be prescribed for other mental health conditions or off-label uses as determined by your healthcare provider.
Bupropion works by increasing levels of norepinephrine and dopamine, two neurotransmitters in the brain that are involved in regulating mood and behavior.
Bupropion is usually taken orally with or without food, as directed by your healthcare provider.
Regular bupropion is taken three times a day (every 6 hours) or four times a day (every 4 hours). Sustained-release bupropion is taken twice a day, and extended-release bupropion is taken once a day (usually in the morning).
The dosage and duration of bupropion treatment depend on your condition and response to the medication. Patients taking bupropion for seasonal affective disorder are usually ordered to start taking it in the fall, continue it through the winter, and stop taking it in the spring.
Follow the prescribed dosage and schedule strictly. Do not stop taking bupropion suddenly without consulting your healthcare provider, as it may cause withdrawal symptoms.
The time it takes to feel the full effects of bupropion can vary from person to person. Some people may notice improvement in their symptoms within a few weeks, while others may require several weeks of treatment.
It's important to continue taking bupropion as prescribed even if you do not feel better immediately. Talk to your healthcare provider if you have any concerns about your treatment.
While bupropion is primarily used for depression, SAD, and smoking cessation, healthcare providers may sometimes prescribe it off-label for other conditions, such as:
Discuss any alternative uses of bupropion with your healthcare provider.
Bupropion is available in the following dosage forms:
Generic versions of bupropion are available under various brand names.
Bupropion is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this antidepressant.
The use of bupropion can lead to various side effects in some individuals.
Common mild side effects of bupropion use include:
More severe side effects of bupropion use can include:
If you experience any severe side effects while taking bupropion, seek immediate medical attention.
Inform your healthcare provider about any existing medical conditions, allergies, or other medications you are taking before starting treatment with bupropion. This includes prescription drugs, over-the-counter medications, and dietary supplements, as they may interact with bupropion.
Tell your provider if you are taking these medications or supplements:
Mention medical conditions such as:
If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using bupropion to assess potential risks and benefits.
Take bupropion exactly as prescribed by your healthcare provider. Do not increase or decrease the dosage without consulting them.
It may take several weeks for bupropion to take full effect. Continue taking the medication even if you do not immediately feel better.
Avoid alcohol while taking bupropion, as it may worsen certain side effects and increase the risk of seizures.
Do not suddenly stop taking bupropion without your healthcare provider's guidance, as it may cause withdrawal symptoms.
In case of a bupropion overdose, seek immediate medical attention. Symptoms may include seizures, hallucinations, rapid heart rate, fainting, and loss of consciousness. If you suspect an overdose, contact the poison control helpline at 1-800-222-1222 or call emergency services.
Bupropion is available in various strengths, including:
The typical starting dose of bupropion for depression, seasonal affective disorder (SAD), smoking cessation, and other conditions can vary depending on factors such as the specific condition being treated, your age, other medical conditions, and how you respond to the medication. It's crucial to follow your healthcare provider's instructions regarding dosage and administration carefully.
For most adults with depression or SAD, the typical starting dose of bupropion may be:
For smoking cessation, the typical starting dose of bupropion may also be:
However, your healthcare provider may start with a lower dose, such as 75 mg for immediate-release tablets, especially for older adults or those with certain medical conditions. The dose may then be gradually increased based on your response and tolerability, up to a maximum of 400 mg (for sustained-release) to 450 mg (for extended-release) per day for depression and 300 mg per day for SAD and smoking cessation.
Bupropion can be taken with or without food, but it's important to take it consistently at the same time each day.
Your healthcare provider will monitor your response to bupropion and may adjust the dose as needed. It's important not to exceed the recommended dose or make changes to your dosage without consulting your healthcare provider.
If you have any questions about your dosage or how to take bupropion, contact your healthcare provider or pharmacist. If you want to talk to a provider right away, consider booking an online doctor appointment on Sesame to discuss your concerns.
If you miss a dose of bupropion, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose of bupropion to make up for a missed one.
Continue taking bupropion as prescribed by your healthcare provider, even if you start feeling better. Abruptly stopping bupropion can lead to withdrawal symptoms and potential relapse of symptoms. Follow your provider's instructions regarding the duration of treatment.
Store bupropion according to the instructions provided by your healthcare provider or pharmacist. It should be kept at room temperature, away from excessive heat, light, and moisture. Ensure the container is tightly closed and keep the medication out of the reach of children.