Medically reviewed by Jessica Swirble, PharmD
Last updated on 4/18/2024

Drug Information | Side Effects | Use & Dosage | Request a Prescription

• Brand Name: Aplenzin, Forfivo, Wellbutrin, Zyban
  
• Generic Name: Bupropion
  
• Uses: Depression, SAD, smoking cessation
  
• Drug Class: Norepinephrine-dopamine reuptake inhibitor (NDRI)
  
• Availability: Prescription only
  
• Generic Status: Yes
  
• Controlled Substance: No
  
  

Bupropion is an antidepressant medication that belongs to the class of drugs known as norepinephrine-dopamine reuptake inhibitors (NDRIs). It is used to treat major depressive disorder (MDD), and seasonal affective disorder (SAD). It is also used to help in smoking cessation (quitting smoking).

Bupropion is used to treat conditions such as:

• Major depressive disorder (MDD)
  
• Seasonal affective disorder (SAD)
  
• Smoking cessation (as part of a comprehensive smoking cessation program)
  
  

It may also be prescribed for other mental health conditions or off-label uses as determined by your healthcare provider.

Bupropion works by increasing levels of norepinephrine and dopamine, two neurotransmitters in the brain that are involved in regulating mood and behavior.

Bupropion is usually taken orally with or without food, as directed by your healthcare provider.

Regular bupropion is taken three times a day (every 6 hours) or four times a day (every 4 hours). Sustained-release bupropion is taken twice a day, and extended-release bupropion is taken once a day (usually in the morning).

The dosage and duration of bupropion treatment depend on your condition and response to the medication. Patients taking bupropion for seasonal affective disorder are usually ordered to start taking it in the fall, continue it through the winter, and stop taking it in the spring.

Follow the prescribed dosage and schedule strictly. Do not stop taking bupropion suddenly without consulting your healthcare provider, as it may cause withdrawal symptoms.

The time it takes to feel the full effects of bupropion can vary from person to person. Some people may notice improvement in their symptoms within a few weeks, while others may require several weeks of treatment.

It's important to continue taking bupropion as prescribed even if you do not feel better immediately. Talk to your healthcare provider if you have any concerns about your treatment.

While bupropion is primarily used for depression, SAD, and smoking cessation, healthcare providers may sometimes prescribe it off-label for other conditions, such as:

• Attention deficit hyperactivity disorder (ADHD)
  
• Depression in patients with bipolar disorder
  
  

Discuss any alternative uses of bupropion with your healthcare provider.

Bupropion is available in the following dosage forms:

• Oral tablets: Available in various strengths (e.g., 75mg, 150mg, 300mg)
  
• Extended-release oral tablets
  
• Oral sustained-release tablets
  
  

Generic versions of bupropion are available under various brand names.

Bupropion is a prescription medication. You will need a valid prescription from a licensed healthcare provider to obtain this antidepressant.