Wellbutrin is generally well tolerated, especially compared to SSRI antidepressants like sertraline or escitalopram.
The most common side effects of bupropion (Wellbutrin) include:
- Agitation
- Blurry vision
- Common cold
- Constipation
- Dizziness
- Dry mouth
- Headaches
- Increased heart rate
- Migraines
- Nausea
- Runny nose
- Sore throat
- Sweating
- Tremors
- Trouble sleeping
- Vomiting
- Weight loss
Compared to other antidepressants, bupropion is four times as likely to cause seizures. This risk is dose-dependent, meaning higher doses are more likely to cause seizures compared to lower doses.
Taking the following medications may also increase your risk of seizures with bupropion:
- Antipsychotics
- Antidepressants
- Benzodiazepines
- Corticosteroids
- Opioids
- Sedatives
- Theophylline
Bupropion can also cause changes in mental health. In people with bipolar disorder, bupropion may cause a manic episode. It can also cause changes in thinking, including paranoia, hallucinations, and suicidal thoughts or behaviors. Report worsening mood or changes in thoughts and behaviors to your provider right away.
Bupropion can also increase the risk of acute angle-closure glaucoma. This occurs when eye drainage is blocked, causing a sudden increase in eye pressure. This is a medical emergency and can lead to vision loss if not treated promptly. Symptoms of acute angle-closure glaucoma include severe eye pain, redness, blurred vision, halos, nausea, and vomiting.