What is entacapone (generic Comtan)?
Entacapone is a medication used to treat symptoms of Parkinson's disease. It belongs to a class of medications known as catechol-O-methyltransferase (COMT) inhibitors that help improve the symptoms of Parkinson's disease, specifically those caused by dopamine deficiency. It is used in combination with the medications levodopa and carbidopa to treat shaking palsy symptoms (commonly referred to as “wearing-off” symptoms) in patients with Parkinson’s.
Entacapone is available under the brand name Comtan and comes in the form of a tablet to take by mouth.
What is entacapone (generic Comtan) used to treat?
Entacapone is used to treat symptoms of Parkinson's disease. Patients with Parkinson’s do not have enough dopamine, a substance that helps to control muscle movements and speech, in their brains. This dopamine deficiency is what causes many of the symptoms of Parkinson’s disease, including tremors, muscle stiffness, slow movements, and poor balance. Entacapone, when used with levodopa and carbidopa, is able to assist with improving dopamine levels, which can help control Parkinson’s disease symptoms.
How does entacapone (generic Comtan) work?
Entacapone belongs to a class of medications known as COMT (catechol-O-methyltransferase) inhibitors. COMT is an enzyme that breaks down levodopa, a substance that is thought to improve dopamine levels in the brain. When COMT breaks down levodopa, the levodopa isn’t able to reach the brain. Entacapone inhibits the COMT enzyme, which prevents it from breaking down levodopa. This means that more levodopa is able to reach the brain, which means that dopamine levels are steadier and Parkinson’s symptoms are more easily controlled.
What are the most common side effects of entacapone (generic Comtan)?
Common side effects of entacapone include:
- Upset stomach
- Movements you cannot control
- Stomach pain
- Muscle breakdown
This is not a complete list of adverse effects – though these are among the most common. Seek medical attention right away if you experience symptoms such as difficulty breathing, hallucinations, high fever, confusion or muscle stiffness while taking entacapone.
As with all prescription medication, be sure to inform the prescribing doctor about any medical conditions you have been previously diagnosed with, as well as any medication/ supplements you are currently taking before starting treatment with entacapone. Entacapone can interact with other forms of medication and substances, causing potentially serious side effects. In addition, let your doctor know if you are pregnant or plan on becoming pregnant before starting treatment with this medication.
What is the typical starting dose of entacapone (generic Comtan)?
Entacapone comes in the form of a tablet which is typically taken with every dose of levodopa and carbidopa. The dosing frequency will vary depending on your diagnosis, ranging from 1-8 times per day. However, you should take the medication exactly as your healthcare provider prescribes. Do not discontinue or increase your dosage of entacapone without consulting with your provider first. If you begin to experience adverse side effects while taking this medication, like those listed above, inform your provider right away.
Entacapone should be stored in a closed container at room temperature, away from extreme heat, extreme cold, moisture, and direct light, and kept out of the reach of children.
Can I get entacapone (generic Comtan) over-the-counter?
Entacapone is currently only available via prescription. This means a licensed health care provider must authorize the use of this drug.
Looking for a prescription? Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you. Book an online consultation with a licensed provider on Sesame today to determine whether or not entacapone is right for you.
Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.
Can I get entacapone (generic Comtan) online?
Good news! If deemed clinically appropriate, providers on Sesame can write a prescription for entacapone to be picked up near you – often within the same day! Simply talk to a clinician and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.
Note that all prescriptions are at the discretion of your healthcare provider.
Which medications can be used to treat Parkinson's disease?