Lowest price carbidopa-levodopa (generic Sinemet) for Parkinson's disease.

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Product Overview

Carbidopa-levodopa (generic Sinemet)

  • What is carbidopa-levodopa?
    Carbidopa-levodopa (generic Sinemet) is a combination of two prescription medications in a single form. It is generally prescribed to treat symptoms of Parkinson’s disease or Parkinson-like symptoms (such as tremors, stiffness, and slowness of movement).

    Levodopa was developed in the late 1960s and is the most potent medication for Parkinson’s disease. Carbidopa prevents the breakdown of levodopa in the bloodstream, allowing more of it to enter the brain, and also helps to reduce some of levodopa’s side effects (such as nausea and vomiting).

  • What are the most common side effects of carbidopa-levodopa?
    Common side effects associated with carbidopa-levodopa include dizziness and/or lightheadedness, nausea, loss of appetite, headaches, and trouble sleeping or unusual dreams.

    Rarely, more serious side effects may occur, including a fast or irregular heartbeat, chest pain, depression, hallucinations, bloody or black stools, excessive vomiting, dyskinesia, and hives. If you experience a severe adverse reaction to carbidopa-levodopa, contact your doctor immediately or seek emergency medical help.

    This is not a complete list of side effects. If you’re concerned about side effects from taking carbidopa-levodopa, contact your doctor directly.

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Frequently asked questions about carbidopa-levodopa

What is carbidopa-levodopa (generic Sinemet)?

Carbidopa-levodopa (generic Sinemet) is a combination of two prescription medications in a single form. It is generally prescribed to treat symptoms of Parkinson’s disease or Parkinson-like symptoms (such as tremors, stiffness, and slowness of movement).

Levodopa was developed in the late 1960s and is the most potent medication for Parkinson’s disease. Carbidopa prevents the breakdown of levodopa in the bloodstream, allowing more of it to enter the brain, and also helps to reduce some of levodopa’s side effects (such as nausea and vomiting).

What is carbidopa-levodopa used to treat?

Carbidopa-levodopa is used to treat symptoms of Parkinson’s disease. It may also be used to treat Parkinson-like symptoms that may develop after encephalitis (swelling of the brain) or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning.

This medication may also be prescribed for other uses. Ask your doctor for more information.

How does carbidopa-levodopa work?

Parkinson’s disease is thought to be caused by not enough dopamine being available in the brain. Dopamine is a neurotransmitter produced by the body that your nervous system used to send messages between nerve cells.

Levodopa belongs to a class of medications known as central nervous system agents. It works by being converted to dopamine in the brain, helping to control movement. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it can reach the brain. This allows not only improves levodopa’s efficacy but also allows for a lower dosage, which helps to reduce some side effects.

What are the most common side effects of carbidopa-levodopa?

It is important to note that if the doctor has prescribed you carbidopa-levodopa it is because they believe its benefits to you outweigh the risks. Common side effects associated with this medication include:

  • Dizziness and/or lightheadedness
  • Nausea and/or vomiting
  • Loss of appetite and/or changes to your sense of taste
  • Headache
  • Trouble sleeping and/or unusual dreams

Talk to your doctor if any of these do not go away or are severe.

Some side effects can be severe. Get immediate medical attention if you experience any of the following:

  • Fast, irregular, or pounding heartbeat
  • Chest pain
  • Depression or harmful/suicidal thoughts
  • Hallucinations
  • Bloody, black, or tarry stools
  • Excessive vomiting, bloody vomit, or vomit that looks like coffee grounds
  • Dyskinesia (involuntary, erratic, writhing movements of the face, arms, legs, and/or trunk)
  • Signs of a severe allergic reaction (such as hives, swelling of the face, throat, tongue, difficulty breathing or swallowing, etc.)

Be sure to tell your doctor if you are pregnant, breastfeeding, have a medical condition, or are taking any other medications.

Please note that this is not a complete list of all possible adverse reactions or precautions. For more information please visit the National Institutes of Health’s DailyMed webpage for carbidopa-levodopa.

How long does it take for carbidopa-levodopa to work?

It may be several months before you experience the full benefits of carbidopa-levodopa. Do not stop taking the medication without consulting your doctor. Carbidopa-levodopa is effective at controlling Parkinson’s disease but does not cure it. You should continue to take it even if you feel well.

What is the typical starting dose of carbidopa-levodopa?

The dosage for this medication is carefully individualized to suit each patient’s specific needs. A typical starting dosage is one 25 mg carbidopa/100 mg levodopa tablet taken three times a day. However, if your dose is different, do not change it unless your doctor tells you to do so. Follow your doctor’s orders or the directions on the label.

Can I get carbidopa-levodopa online?

Yep! With Sesame Rx, you can get medication delivered right to your door starting at just $5 per month - without insurance. Our fully integrated prescription service lets your doctor write you a prescription (or refill an existing one) during your virtual or in-person visit. That way, you can focus on getting better and not worry about how and when you’ll get your prescription.

Please note that all prescriptions are at the discretion of your doctor.

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