Spironolactone is a prescription medication used to treat a variety of conditions. It helps remove excess salt and water from the body, which can lower blood pressure and reduce swelling.

Common medical uses include high blood pressure, heart failure, fluid retention caused by kidney or liver disease, and certain hormonal conditions. In some cases, healthcare providers may also prescribe it off-label for acne or excessive hair growth in females.

Spironolactone can help with acne by blocking the effects of androgens, hormones that increase oil production in the skin. By reducing excess oil, it can decrease the formation of acne over time. Results typically appear gradually, with some improvement seen after a few weeks and more noticeable effects after several months of consistent treatment.

If you’re struggling with acne, a Sesame provider can help determine whether spironolactone or another acne treatment is right for you.

Oral spironolactone is taken by mouth and affects the whole body, allowing it to treat conditions like high blood pressure and edema while also addressing hormonal imbalances.

Topical spironolactone acne medication is not an FDA‑approved, widely manufactured product. Dermatologists may prescribe compounded topical formulations prepared by licensed pharmacies for acne in some cases. These still require a prescription and are not available over the counter.

Spironolactone is not recommended for people with kidney or liver disease, high potassium levels (hyperkalemia), or Addison’s disease or other electrolyte imbalances.

People taking certain medications or supplements, like ACE inhibitors, ARBs, potassium supplements, NSAIDs, digoxin, lithium, or other diuretics, should consult their provider before starting spironolactone due to potential drug interactions.

Individuals who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their provider before starting.

Spironolactone is a prescription-only medication. You must see a licensed healthcare provider to get a prescription. Providers on Sesame can write a prescription or refill an existing one during a virtual or in-person visit, often with same-day pickup at a pharmacy near you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

There are several different diuretic medications used to help the body remove excess fluid and lower blood pressure. Thiazide‑type diuretics include chlorthalidone (generic for Thalitone), hydrochlorothiazide (generic for Esidrix), and indapamide (generic for Lozol).

Loop diuretics, such as furosemide and torsemide (generic for Demadex), are often used when more potent fluid removal is needed. Potassium‑sparing options include spironolactone and combinations like triamterene‑HCTZ. These drugs help prevent the loss of potassium while still reducing fluid retention.