Weight-loss medications can be helpful tools for some people when combined with lifestyle changes like a reduced-calorie diet and physical activity. They are generally most effective for adults with obesity or those who are overweight with weight-related health conditions.

These medications are not quick fixes. They help support appetite control, reduce cravings, or change how the body processes food, but sustainable weight loss still relies on healthy habits and consistent behavior changes.

Different weight-loss medications work in different ways. Contrave weight loss pills combine bupropion and naltrexone to act on the brain’s appetite and reward pathways. This helps reduce hunger, increase feelings of fullness, and decrease cravings.

Other medications, like GLP-1 receptor agonists (e.g., semaglutide), slow stomach emptying and affect satiety hormones, so the approach can vary depending on the drug.

Results vary between individuals, but studies show that adults taking Contrave alongside diet and exercise typically lose more weight than those following lifestyle changes alone.

In clinical trials, people lost 5% or more of their starting weight, compared to placebo groups that lost about 1-2%. Effectiveness depends not only on the weight loss drugs, but also on consistent dosing and lifestyle efforts.

Whether Contrave is safe for you depends on your medical history. People with uncontrolled high blood pressure, seizure disorders, certain eating disorders, chronic opioid use, or who are taking other bupropion-containing medications to treat depression may not be able to take it.

Always discuss your health conditions, medications, and supplements with your provider before starting Contrave to ensure it’s appropriate and safe for you.

Contrave and Ozempic (semaglutide) are both prescription options for weight management, but they work differently. Contrave is an oral medication combining bupropion and naltrexone to target appetite and cravings in the brain.

Ozempic is a GLP-1 receptor agonist, usually given as a once-weekly injection, which slows stomach emptying, increases feelings of fullness, and affects blood sugar regulation. Both can support weight loss, but the choice depends on existing health conditions, lifestyle preferences, and guidance from your healthcare provider.

Before starting Contrave, it’s important to review your full medical history with your healthcare provider. Be upfront about any past or current health conditions, including seizures, eating or mood disorders, high blood pressure, diabetes, low blood sugar, liver or kidney issues, heart disease, or a history of alcohol or substance use.

Let your provider know about any medications, supplements, or over-the-counter products you take to avoid drug interactions. If you are pregnant, planning to become pregnant, or breastfeeding, weigh the potential benefits and risks with your provider.

Contrave is available by prescription only. You need prior authorization from a licensed healthcare provider to use this medication. You can book a video weight loss program through Sesame to discuss treatment options with a licensed healthcare provider. Contrave can be prescribed during these appointments, if deemed appropriate by your provider.

Note that all prescriptions are at the discretion of your healthcare provider. Sesame cannot guarantee that you will be provided a prescription after a video or in-person appointment.

There are several brand-name drugs and generic prescription medications available to help with weight loss, each working in slightly different ways. Ozempic (semaglutide), liraglutide, and Wegovy (semaglutide) are part of a class called GLP-1 receptor agonists. They work by slowing digestion and helping you feel full, which can reduce calorie intake.

Ozempic alternatives like Zepbound (tirzepatide) are another option. This drug also targets appetite and blood sugar regulation to support weight loss. Your healthcare provider can help determine which option might be right for you.