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Product Overview

Lisinopril-HCTZ (generic Zestoretic)

  • What is lisinopril-HCTZ?
    Lisinopril-HCTZ (generic Zestoretic) is a prescription medication generally used to treat high blood pressure. Lisinopril-HCTZ is actually a combination of the prescription drugs lisinopril and hydrochlorothiazide in a single form. Lisinopril belongs to a class of medications called ACE inhibitors, which decrease certain chemicals that tighten blood vessels. Hydrochlorothiazide is a thiazide diuretic (sometimes called a “water pill”) that helps to rid the body of excess water and salt.

    Lisinopril-HCTZ is used alongside healthy lifestyle changes (such as a diet low in fat and salt, regular exercise, maintaining a healthy weight, and abstaining from smoking and alcohol) to treat high blood pressure (hypertension).

  • What are common side effects of lisinopril-HCTZ?
    Many people who take lisinopril-HCTZ have no side effects. However, in some cases, lisinopril-HCTZ has been known to cause a dry, tickly cough, dizziness, headaches, diarrhea, fatigue, heartburn, and decreased sexual ability. Rarely, more serious side effects occur, such as fainting, eye pain, and more.

    This is not a complete list of side effects. If you are concerned about additional side effects from taking lisinopril-HCTZ, please talk to your doctor directly.

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Medically Reviewed By Dr. Allison Edwards, MD

Frequently asked questions about Lisinopril-HCTZ

Lisinopril-HCTZ (generic Zestoretic) is a prescription medication generally used to treat high blood pressure. Lisinopril-HCTZ is a combination of the prescription drugs lisinopril and hydrochlorothiazide in a single form. Lisinopril belongs to a class of medications called ACE inhibitors, which decrease certain chemicals that tighten blood vessels. Hydrochlorothiazide is a thiazide diuretic (sometimes called a “water pill”) that helps to rid the body of excess water and salt.

Lisinopril-HCTZ is used alongside healthy lifestyle changes (such as a diet low in fat and salt, regular exercise, maintaining a healthy weight, and abstaining from smoking and alcohol) to treat high blood pressure (hypertension).

Lisinopril-HCTZ is used to treat high blood pressure. High blood pressure is a common but serious disease. When not treated, it can lead to serious complications such as heart disease, heart attacks, kidney failure, loss of vision, strokes, and more.

This medication may also be prescribed for other uses. Talk to your doctor to find out if Lisinopril-HCTZ is right for you.

Lisinopril belongs to a group of drugs known as ACE inhibitors (“ACE” stands for Angiotensin-converting-enzyme). ACE inhibitors help your blood vessels relax and expand by blocking a certain chemical (angiotensin II) known to restrict them. This lowers your blood pressure and makes it easier for your heart to pump blood and oxygen around your body.

Hydrochlorothiazide belongs to a family of drugs known as thiazide diuretics, which are sometimes also known as “water pills.” These medicines work by stimulating your kidneys to get rid of your body’s excess salt and water via urine.

It is important to note that if the doctor has prescribed you lisinopril-HCTZ it is because they believe its benefits to you outweigh the risks. Many people who take lisinopril-HCTZ have no side effects or only minor ones. However, adverse effects sometimes do occur.

The most common side effects include:

  • A dry, tickly cough
  • Dizziness or lightheadedness
  • Headaches
  • Diarrhea or nausea
  • Fatigue
  • Decrease in sexual ability
  • Heartburn

Most of these side effects often go away as your body adjusts to the medication. Talk to your doctor if they do not go away or are severe.

Serious side effects are uncommon but do occur. Seek immediate medical attention if you experience any of the following:

  • Fainting
  • Decrease in vision or eye pain
  • Changes in your heartbeat
  • Increased/ decreased urine volume
  • Skin rash
  • Hives
  • Swelling of the face, lips, hands or feet

Be sure to tell your doctor if you are pregnant, breastfeeding, have a medical condition, or are taking any other medications.

Please note that this is not a complete list of all possible adverse reactions or precautions. For more information please visit the National Institutes of Health’s DailyMed webpage for lisinopril-HCTZ.

You can expect noticeable improvements to your blood pressure after about two weeks of taking it. However, it can take two to four weeks before you experience the full benefit of lisinopril-HCTZ.

You should continue to take lisinopril-HCTZ even if you feel well. High blood pressure often doesn’t have any noticeable symptoms. While this medication is effective at controlling your blood pressure, it does not cure it. Talk to your doctor if you want to discontinue using lisinopril-HCTZ.

Doctors usually prescribe lisinopril-HCTZ if therapy with either lisinopril or hydrochlorothiazide alone has not yielded the desired results or if a higher monotherapy dose of either medication resulted in adverse effects (most commonly a potassium deficiency because of the diuretic properties of hydrochlorothiazide).

The dose prescribed to you will be individualized to your needs based on how your body has reacted to the monotherapy and several other factors. A typical starting dose, however, is 10 to 20 mg of lisinopril and 12.5 mg of hydrochlorothiazide.

Take lisinopril-HCTZ only as instructed by your doctor. Do not take more or less of it or take it more often than prescribed by your doctor.

Lisinopril-HCTZ is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Looking for a prescription? Good news! Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not lisinopril-HCTZ is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Yes! Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.

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