Get a Foundayo® (orforglipron) pill prescription online for weight loss today!

There are currently five GLP-1 medications approved for weight loss: Zepbound (tirzepatide injection), Wegovy (semaglutide injection), Wegovy pill (oral semaglutide), Foundayo (orforglipron), and Saxenda (liraglutide). Based on clinical trial data, Zepbound produces the greatest average weight loss, followed by Wegovy injection, the Wegovy pill, and Foundayo.

Here's how they compare:

• Zepbound (injectable tirzepatide): Average weight loss of about 20% at 72 weeks, making it the top performer in head-to-head trials against semaglutide.
• Wegovy (injectable semaglutide): Average weight loss of around 15% at 68 weeks. A well-established injectable option with strong clinical evidence.
• Wegovy pill (oral semaglutide): Average weight loss of around 14% at 68 weeks, and requires strict fasting and water-only dosing conditions.
• Foundayo (oral orforglipron): Average weight loss of around 11% at 72 weeks. While it leads to slightly less weight loss than tirzepatide and semaglutide, it is the only GLP-1 pill with no food or water restrictions, making it the most convenient oral option.
• Saxenda (injectable liraglutide): Average weight loss of around 8% at 56 weeks. It is the least effective weight loss GLP-1 medication.

Keep in mind that results vary from person to person, and the most effective medication for you depends on your health history, goals, and lifestyle.

Yes. If Foundayo is deemed clinically appropriate, you can receive a prescription through reputable online weight loss programs like Success by Sesame. You’ll meet with a licensed medical provider who can evaluate you and, if appropriate, write a prescription for Foundayo or another GLP-1 medication like Zepbound or Wegovy.

Once you have the prescription, you’ll be able to purchase Foundayo by filling your Rx at your preferred pharmacy—either through an online pharmacy or an in-person/local pharmacy.

Yes, switching from injections to an oral GLP-1 is possible!

If you're switching from an injectable GLP-1 like Zepbound or Wegovy to Foundayo, your Sesame doctor may have you start at a lower dose and then gradually work up to a target maintenance dose.

The timing of your first dose of Foundayo may also depend on how long your previous injection stays active in your body. Always consult your Sesame provider before making any changes to your treatment.

Yes. Both FDA-approved oral GLP-1 options have shown meaningful results in clinical trials. The Wegovy pill delivered a mean weight loss of 13.6% at 68 weeks in the OASIS 4 trial, while Foundayo (orforglipron) showed an average weight reduction of 11% at 72 weeks.

While oral options generally produce slightly less weight loss than injectable GLP-1s, they offer a convenient, needle-free alternative. Results can also vary significantly from person to person, which is why personalized clinical guidance is so essential.