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Product Overview

Metformin ER (generic Glucophage XR)

  • What is metformin ER?
    Metformin ER is the extended-release version of metformin, a prescription drug used to treat type 2 diabetes. Metformin decreases your body’s blood glucose level and increases its response to the hormone insulin to get your type 2 diabetes under control.

    Looking for a safe, effective way to keep your diabetes under control? Talk to your doctor about whether metformin may be right for you.

  • What are the most common side effects of metformin ER?
    While adverse reactions to metformin are uncommon, some patients who take the drug may experience mild side effects, including diarrhea, nausea, flatulence, asthenia, indigestion, abdominal discomfort, and headache.

    Rare, more serious adverse events have also been known to occur. If you are concerned that metformin may be causing you to experience any number of adverse side effects, contact your doctor or clinician.

    This is not a complete list of side effects. For more information on side effects you may experience while taking metformin, visit the National Institutes of Health’s DailyMed for more information.

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Medically Reviewed By Dr. Allison Edwards, MD

Frequently Asked Questions About Metformin ER

Metformin ER is the extended-release version of metformin, a prescription drug used to treat type 2 diabetes. Metformin decreases your body’s blood glucose level and increases its response to the hormone insulin to get your type 2 diabetes under control.

Nearly 1 in 10 Americans has diabetes, a condition characterized by elevated levels of glucose - or sugar - in the blood. If left untreated, elevated glucose levels can wreak havoc on your body, causing kidney damage, eye problems, sexual dysfunction, and more. Doctors prescribe drugs like metformin to help keep patients’ blood glucose - and their diabetes symptoms - in check.

Metformin ER is used to treat type 2 diabetes - the form of diabetes in which the body either does not produce enough insulin or builds a resistance to it.

Insulin is a hormone that plays a role in the way your body takes up and uses sugar for energy. When your body does not produce enough insulin, sugar builds up in the blood, leading to serious problems like kidney problems, eye problems, heart disease, nerve damage, loss of limbs, and even death.

Metformin ER cannot be used to treat type 1 diabetes, a condition in which the body produces little to no insulin at all.

It is important to note that metformin is meant to work alongside diet, exercise, and lifestyle changes to lower your blood glucose levels and bring your diabetes under control. Metformin alone is not sufficient to treat your blood glucose imbalance.

Metformin belongs to a series of medications known as biguanides. This family of drugs decreases the amount of glucose your body absorbs from food and limits the amount of glucose your body naturally produces. Metformin also enhances your body’s response to insulin, a hormone responsible for regulating your blood glucose levels. The combined effect of these actions helps keep your blood glucose level under control.

While there are some common side effects associated with metformin, it is important to remember that your doctor prescribed it because they believe its ability to manage symptoms outweighs any adverse effects it may cause. The most common side effect of metformin ER include:

  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Asthenia
  • Indigestion
  • Abdominal discomfort
  • Headache

Rare but potentially serious side effects may include:

  • Lactic acidosis
  • Hypothermia
  • Hypotension

This is not an exhaustive list of side effects associated with metformin. For a complete list of metformin side effects, visit the National Institutes of Health’s DailyMed website for more information.

It may take up to 4 or 5 days before metformin will take full effect, but you may notice a difference within 48 hours after starting the medication. It is important to continue taking this medication even if you feel well. Most people with diabetes need to continue taking medications for the rest of their lives.

The recommended starting dose for metformin ER is 500 mg, taken once daily. You should take this pill orally with your evening meal. Your doctor will need to check your progress on a regular basis while you are taking this medication. Based on how your body responds, your doctor may increase your dosage up to a daily maximum of 2000 mg. Do not miss any scheduled visits to your doctor.

Your doctor may increase your dosage based on your medical condition and response to therapy.

Metformin ER is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not metformin ER is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Yes! Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.

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