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Product Overview

Glyburide/Metformin (generic Glucovance)

  • What is glyburide-metformin?
    Glyburide-metformin (generic Glucovance) is a prescription medication used to treat type 2 diabetes. As with many diabetes medications, glyburide-metformin works best when taken alongside lifestyle changes that naturally stabilize your insulin levels, including diet, exercise, and weight loss.

    Looking for a safe, effective way to manage your type 2 diabetes? Talk to your doctor about whether glyburide-metformin is right for you.

  • What are common side effects of glyburide-metformin?
    While adverse reactions to glyburide-metformin are uncommon, some patients who take the drug may experience mild side effects, including stomach pain, nausea, vomiting, diarrhea, and dizziness.

    Rare, more serious adverse events have also been known to occur, including chest pain, rash, yellowing of the skin or eyes, light-colored stools, dark urine, stomach pain, unusual bleeding or bruising, fever, sore throat, and swelling of the eyes, face, lips, tongue, or throat.

    If you are concerned that glyburide-metformin may be causing you to experience any number of adverse side effects, please contact your doctor immediately or seek emergency care.

    This is not a complete list of glyburide-metformin side effects. For more information on adverse side effects you may experience while taking glyburide-metformin, please visit the National Institutes of Health’s DailyMed webpage.

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Medically Reviewed By Dr. Allison Edwards, MD

Frequently asked questions about Glyburide/Metformin

Glyburide-metformin (generic Glucovance) is a prescription medication used to treat type 2 diabetes.

Nearly 1 in 10 Americans has diabetes, a condition characterized by elevated levels of glucose - or sugar - in the blood. If left untreated, elevated glucose levels can wreak havoc on your body, causing kidney damage, eye problems, sexual dysfunction, and more. Doctors prescribe drugs like glyburide-metformin to help keep patients’ blood glucose - and their diabetes symptoms - in check. Glyburide-metformin is only used to treat type 2 diabetes and is not approved for other forms of the condition.

As with many diabetes medications, glyburide-metformin works best when taken alongside lifestyle changes that naturally stabilize your insulin levels, including diet, exercise, and weight loss.

Looking for a safe, effective way to manage your type 2 diabetes? Talk to your doctor about whether glyburide-metformin is right for you.

Glyburide-metformin is used to treat type 2 diabetes. It is not prescribed to treat type 1 diabetes.

Glyburide-metformin is a combination drug comprised of both glyburide and metformin.

Glyburide belongs to a class of medications known as sulfonylureas. These drugs help lower your blood sugar by causing the pancreas to produce insulin and helping your body use and manage insulin more efficiently. Insulin is the chemical that breaks down and regulates sugar in your body.

Metformin, on the other hand, belongs to a family of medications known as biguanides. Biguanides control the amount of glucose in your blood. They help you use insulin more efficiently by limiting the amount of glucose you absorb from food and the amount your liver naturally produces.

While adverse reactions to glyburide-metformin are uncommon, some patients who take the drug may experience mild side effects, including stomach pain, nausea, vomiting, diarrhea, and dizziness.

Rare, more serious adverse events have also been known to occur, including chest pain, rash, yellowing of the skin or eyes, light-colored stools, dark urine, stomach pain, unusual bleeding or bruising, fever, sore throat, and swelling of the eyes, face, lips, tongue, or throat.

If you are concerned that glyburide-metformin may be causing you to experience any number of adverse side effects, please contact your doctor immediately or seek emergency care.

This is not a complete list of glyburide-metformin side effects. For more information on adverse side effects you may experience while taking glyburide-metformin, please visit the National Institutes of Health’s DailyMed webpage.

Many patients begin to notice improvement within 1-2 weeks of starting glyburide-metformin. It is important to continue taking glyburide-metformin for as long as your doctor prescribes, even if you begin to feel better. Do not stop taking glyburide-metformin without consulting your doctor.

In most patients, the recommended starting dose is 1.25 mg of glyburide and 250 mg of metformin, taken once or twice daily with meals.

For patients who have been treated, though not adequately, on glyburide or metformin alone, the recommended starting dose is 2.5mg glyburide/500 mg metformin, taken once or twice daily with meals.

Your doctor may gradually increase your dose to a maximum daily intake of 20 mg glyburide/2000 mg metformin.

Talk to your doctor about a starting dose that works for you.

Glyburide-metformin is currently only available via prescription. This means the use of this drug must be authorized by a licensed health care provider.

Looking for a prescription? Good news! Providers on Sesame can write a prescription – or refill an existing one – during a virtual or in-person visit. Depending on the medication, you can arrange for same-day pickup at a pharmacy near you. Book an online consultation with a real, licensed provider on Sesame today to determine whether or not glyburide-metformin is right for you.

Note that all prescriptions are at the discretion of your health care provider. Providers on Sesame cannot prescribe controlled substances.

Yes! Talk to a provider on Sesame and get your online doctor prescription or refill ordered right away for fast and convenient pickup from a pharmacy of your choice.

Note that all prescriptions are at the discretion of your clinician.

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