Mirtazapine is a prescription-only atypical antidepressant primarily used to treat major depressive disorder.

It works by restoring the balance of natural chemicals in the brain that help with mood regulation to improve your overall well-being.

On Sesame, you pay a one-time cost to book a video consultation with a licensed MD, PA, or clinician for a mirtazapine prescription or refill. Consultation prices are clearly displayed on each provider’s profile. You pay only what you see for your visit, no insurance required.

Your medication is paid for at the pharmacy. The price may differ depending on the pharmacy and whether you use insurance.

Mirtazapine can interact with medications, including other antidepressants and medications that cause drowsiness. Do not take mirtazapine with MAO inhibitors, as this combination can cause serious, sometimes fatal reactions.

Make sure you share a complete list of any prescription medicines, OTC medicines, and supplements with your provider during your telehealth visit, so they can determine an appropriate personal treatment plan before you start mirtazapine.

No, mirtazapine and Xanax are different classes of medication.

Mirtazapine is a tetracyclic antidepressant used for major depressive disorder. Xanax (alprazolam) is a benzodiazepine typically prescribed for anxiety and panic disorders.

Taking mirtazapine daily can help to maintain mental balance over a longer term, while Xanax is typically used for more immediate relief from acute anxiety or panic attacks.

Many patients notice improved sleep within the first week of taking mirtazapine, before any noticeable mood changes.

Do not drive or operate heavy machinery while taking mirtazapine until you know how the drowsiness affects you personally.

You can book a visit with a licensed clinician on Sesame 24/7 for new mirtazapine prescriptions or refills, typically covering 1–2 refills per visit.

While Sesame is a cash-pay marketplace and doesn't accept insurance for your consultation, you can use your insurance at the pharmacy to cover your mirtazapine cost.

Having your current prescription bottles or Rx ready can help your provider confirm your Rx details.

Take mirtazapine as soon as you remember if you miss a dose, but skip it if it's almost time for your next pill.

Don't exceed the dosage recommended by your provider to make up for a missed one.

Before starting mirtazapine, tell your provider if any of the following apply to you:

• History of seizures, heart disease, or kidney or liver problems
• High cholesterol, glaucoma, or diabetes
• Low blood pressure
• Pregnancy, planning to become pregnant, or breastfeeding
• Currently taking or have taken an MAO inhibitor in the last 14 days
• Bipolar disorder or a history of mania/hypomania
• Lactose intolerance
• Phenylketonuria

Call the poison control helpline at 1-800-222-1222 or seek emergency medical care right away.

Symptoms of mirtazapine overdose may include:

• Disorientation
• Extreme sleepiness
• Rapid heart rate

Common alternatives to mirtazapine include SSRIs like sertraline (Zoloft) and escitalopram (Lexapro), as well as other antidepressants like nortriptyline and bupropion (Wellbutrin).

A provider on Sesame can help you figure out which option is the best fit for your specific needs.