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Get a progesterone (Prometrium) prescription online for menstrual and menopausal care

  • Same-day prescriptions
  • Local pharmacy pick-up
  • Rx discount card available

Book care online with a Sesame provider and get a progesterone prescription online if it’s right for you. Progesterone is a hormone used to regulate menstrual cycles, manage abnormal uterine bleeding, and protect the uterine lining for people taking estrogen.

This medication can help you:

  • Restart absent or irregular periods
  • Treat hormone-related abnormal uterine bleeding
  • Support healthy endometrial changes during hormone treatment

Get a prescription today

Why order a progesterone prescription online through Sesame?

About progesterone

Learn more about progesterone, what it’s used to treat, and how to get progesterone prescribed today.

Get the prescriptions you need at Sesame’s always-low prices.

How to get progesterone pills online through Sesame

1
Choose a provider

Browse our website, where you can read reviews and check prices. You can then book a same-day appointment with a provider of your choice to discuss whether progesterone is right for you.

2
Meet with your provider

You will join your provider on a live video call to discuss your health and whether progesterone is a good treatment option for you.

3
Get your progesterone prescription online

If appropriate, your provider can send your progesterone prescription to the pharmacy of your choice. It can be sent to an online pharmacy for shipping directly to you, or to a nearby pharmacy for convenient same-day pickup.

Progesterone possible side effects and safety considerations

Learn about potential side effects and when to seek medical care

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Frequently asked questions

About progesterone prescriptions

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Medically reviewed by:Jessica Swirble, PharmD

Progesterone pills are primarily used in combination with estrogen for hormone replacement therapy during menopause and perimenopause. Progesterone can help reduce menopausal symptoms and protect the uterus from endometrial overgrowth, which increases cancer risk.

Progesterone comes in other formulations, including vaginal gel, a vaginal insert, and an intramuscular injection. These are typically used for infertility treatment, IVF, abnormal bleeding, and the absence of menstruation.

Progesterone pills are not available over the counter. They are available by prescription only from a licensed provider.
Schedule a same-day appointment with a Sesame provider and get a prescription for progesterone today. All prescriptions are at the discretion of the provider.

Yes, you can get a new prescription or a refill for progesterone pills online after an appointment with a Sesame provider. Simply schedule an appointment on the website, possibly even the same day. During the appointment, your provider will review your medical history, current medications, and health concerns.

If appropriate, your provider can send the prescription to an online pharmacy for home delivery or to a local pharmacy for same-day pickup. All prescriptions are at the discretion of the provider.

Progesterone should help you feel better, but it can also cause side effects. The following are possible side effects of progesterone pills:

  • Drowsiness
  • Headache
  • Weight changes
  • Nausea
  • Vomiting
  • Breast tenderness or pain
  • Menstrual irregularity and changes

Progesterone pills can help balance hormones and are used for menstrual and menopausal support.

Benefits of progesterone:

  • Regulates the menstrual cycle
  • Reduces heavy menstrual bleeding
  • Protects the uterus during hormone replacement therapy
  • Reduces hot flashes
  • Improves mood
  • Promotes restful sleep
  • Supports bone health
  • Improves skin and hair

Grapefruit juice can increase the effect of progesterone, leading to an increased risk of side effects. Other than grapefruit juice, foods do not interact with progesterone, but certain foods can increase menopausal symptoms. Alcohol, spicy foods, caffeine, processed foods, and foods high in sugar can lead to hot flashes, bloating, and insomnia.

Progesterone can interact with some medications. Always tell your provider about all prescription and over-the-counter medications, vitamins, minerals, and supplements you take. The following medications may interact with progesterone:

  • Antibiotics
  • Antifungals
  • Diabetic medications
  • HIV medications
  • Seizure medications
  • St. John’s wort

Progesterone pills may not be safe or appropriate for everyone. Before taking progesterone, you should tell your provider if you have or have had any of the following conditions:

  • Peanut allergy
  • Sesame allergy
  • History of blood clots
  • Liver disease
  • Abnormal uterine bleeding
  • Breast cancer
  • Cervical, endometrial, ovarian, uterine, or vaginal cancer

It is important to have a conversation with your provider about whether progesterone is right for you. They can review your medical history, current medications, and health concerns to determine if progesterone is a good option.

Interested in speaking with a provider? You can schedule an online appointment with a Sesame provider at a time that is convenient for you.

Progesterone is commonly used together with estrogen for hormone replacement therapy in menopausal women. This can ease symptoms of hot flashes, mood swings, and vaginal dryness. It can also protect against osteoporosis.

In women who still have a uterus, estrogen is given with progesterone to protect the uterus. Estrogen can thicken the endometrial lining, which can increase the risk of endometrial cancer. Progesterone thins the lining, reducing the risk of overgrowth.