You should avoid combining sumatriptan tablets with other migraine drugs in the same class, like zolmitriptan, or with ergot-based medications like ergotamine or dihydroergotamine.

You should also avoid using this drug with monoamine oxidase (MAO) inhibitors, including isocarboxazid, phenelzine, or tranylcypromine. MAO inhibitors increase serotonin levels, and combining them with medications like sumatriptan can raise your risk of a serious reaction called serotonin syndrome. Be cautious when taking sumatriptan alongside antidepressants like SSRIs or SNRIs (like duloxetine) for the same reason.

Alcohol may worsen side effects like dizziness or fatigue, so it’s best to limit or avoid it altogether. Avoid taking more than the recommended dose or using sumatriptan too frequently, as this can lead to medication overuse headaches.

If you’re unsure about drug interactions or what’s safe to take together, check with your pharmacist or healthcare provider for medical advice before using sumatriptan for migraines.

Sumatriptan isn’t taken on a regular schedule. You take it only when a migraine starts. If you didn’t take it at the first sign of a migraine, you can still take a dose later during the attack. If your symptoms improve but come back, you may be able to take another dose after at least 2 hours, as long as you don’t exceed the maximum daily limit (typically 200 mg).

If you’re unsure when or how often to take this medicine, check with your healthcare provider for guidance.

Taking more sumatriptan than recommended can increase your risk of side effects, like severe dizziness, drowsiness, or weakness. In more serious cases, taking too much can affect your heart or blood vessels, potentially causing chest pain, changes in blood pressure, or abnormal heart rhythms. It may also increase the risk of serotonin syndrome.

If you think you’ve taken too much sumatriptan or are experiencing unusual or severe symptoms, seek medical attention right away or contact your local poison control center.

Sumatriptan is prescription-only. As with all prescription medications, you’ll need to meet with a licensed healthcare provider first before you can get it.

If you think sumatriptan may be right for you, a provider at Sesame can evaluate your symptoms and medical history during a convenient video visit to determine whether it’s an appropriate treatment. They can write a prescription for you at that visit to fill at your preferred pharmacy.

Keep in mind that all prescriptions are issued at your provider’s discretion, and not everyone is a good candidate for sumatriptan.

You can meet with a licensed Sesame provider online to discuss your migraines. If sumatriptan is appropriate, your provider can send a prescription directly to a pharmacy near you for fast, convenient pickup. Note that all prescriptions are at your provider’s discretion.

For ongoing prescriptions and home delivery, you can use Sesame Everyday Rx, a subscription service that offers convenient refills, $1 medications, and access to a dedicated provider.

Medications used to treat migraines vary depending on whether you’re trying to stop a migraine that is already happening or prevent future attacks. For fast relief, drugs like sumatriptan, eletriptan, and rizatriptan belong to a class called triptans, which work by narrowing blood vessels in the brain and blocking pain signals during an active migraine.

Other medications are used more for prevention. Topiramate is commonly prescribed to reduce how often migraines occur. Amitriptyline, an antidepressant, and metoprolol, a beta-blocker, are often used off-label to help reduce the number of migraines you experience.

Meeting with a [provider on Sesame for migraine treatment](https://sesamecare.com/complaint/migraine can help you decide which treatment option is right for you based on your medical history and how often your migraines occur.