Sesame Logo

Get a trazodone prescription online for depression and sleep support

  • Same-day prescriptions
  • Local pharmacy pick-up
  • Rx discount card available

Book care online with a Sesame provider and get a trazodone prescription if it’s right for you. Trazodone is an FDA-approved medication used to treat major depressive disorder (MDD) by helping balance serotonin levels in the brain. Its calming effects also make it commonly prescribed off-label to support better sleep and manage insomnia.

This medication can help you:

  • Manage symptoms of depression
  • Stabilize mood and emotions
  • Improve overall sleep quality

Get a prescription today

Why order a trazodone (generic Desyrel) prescription online through Sesame?

About trazodone (generic Desyrel)

Learn more about trazodone, what it's used to treat, and how to get trazodone prescribed today.

Get the prescriptions you need at Sesame’s always-low prices.

Enter your email to get 20% off your first appointment.

How to get trazodone (generic Desyrel) prescribed online through Sesame

1
Choose a provider

Browse licensed clinicians, compare pricing, and book a visit that works for your schedule.

2
Meet with your provider

Connect via secure video to review your symptoms, medical history, and treatment goals.

3
Get your trazodone prescription online

If appropriate, your provider can send your trazodone prescription directly to your preferred pharmacy, often the same day.

Trazodone (generic Desyrel) possible side effects and safety considerations

Learn about potential side effects and when to seek medical care.

Patients love Sesame

Frequently asked questions

About trazodone (generic Desyrel) prescriptions

Avatar image
Medically reviewed by:Dr. Allison Edwards, MD

Trazodone may help manage symptoms of anxiety, though it is not FDA-approved specifically for this purpose. Its calming effects can reduce tension, promote relaxation, and support better sleep, which may indirectly improve anxiety symptoms.

Trazodone is sometimes used off-label for generalized anxiety disorder (GAD), panic disorder, or sleep disturbances related to anxiety. Always discuss your specific symptoms with a healthcare provider to determine if trazodone is appropriate for you.

Providers typically prescribe lower doses for anxiety than those used for depression, often starting around 25 to 150 mg per day, depending on your response to the medication. Your provider will tailor the dose carefully based on your unique medical history and symptoms.
Trazodone’s effects can vary. Some individuals notice improved sleep shortly after the first dose, while others may take several weeks to experience meaningful improvements in mood or anxiety symptoms. Consistent use as prescribed is essential to achieve the desired effects.

Trazodone can interact with certain medications, so it’s important to tell your provider about all prescriptions, over-the-counter drugs, supplements, and herbal remedies you take.

This includes MAO inhibitors such as isocarboxazid or phenelzine, other antidepressants and anti-anxiety drugs like amitriptyline or buspirone, migraine medications such as sumatriptan or Relpax, anticoagulants like apixaban, herbal supplements like St. John’s wort, and heart medications like amiodarone. Your provider can review potential interactions and adjust your treatment safely.

For depression, your provider may recommend dividing the total daily dose into morning and evening doses to improve tolerability and effectiveness. For sleep support, trazodone is typically taken shortly before bedtime due to its sedating effects. Learn more about how much sleep you actually need per night in our guide to sleep loss and how to get better rest.
Trazodone can be taken with or without food, but you may experience less nausea when taken with a light meal. Taking it on an empty stomach is generally safe, but your provider may provide individualized guidance based on your tolerance.
Trazodone should be stored at room temperature, away from excessive heat, moisture, and direct sunlight. Keep the medication in its original container with the lid tightly closed and out of reach of children.
If you miss a dose of trazodone, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue as prescribed. Do not double up on doses to make up for a missed one, as this can increase the risk of side effects.

Trazodone is currently only available via prescription. This means the use of this drug must be authorized by a licensed healthcare provider.

If you're looking for a trazodone online prescription, book a telehealth appointment through Sesame. Our providers can write a new prescription or refill an existing one if appropriate. Note that all prescriptions are at the discretion of your healthcare provider. Providers on Sesame cannot prescribe controlled substances.

To get a trazodone prescription, you need to consult with a licensed healthcare provider. This can be done in person or through a video visit with Sesame. During the appointment, your provider will review your medical history, current medications, and symptoms to determine whether trazodone is appropriate for you.

If prescribed, your provider can send the medication directly to your preferred pharmacy, often the same day, so you can start treatment without delay. Keep in mind that all prescriptions are at the discretion of your provider, and a consultation does not guarantee that trazodone will be prescribed.

Your provider may also suggest other medications or treatment options, whether you’re seeking trazodone as a mental health medication or to manage insomnia.