Sesame vs. Ro Weight Loss 2026: Similarities and Differences

Online weight loss programs have made it easier than ever to access prescription GLP-1 medications like Wegovy®, Zepbound®, and Ozempic®. Instead of visiting an in-person clinic, you can now meet with licensed providers virtually, manage prescriptions through an app, and have medications delivered to your door.

Two well-known options in this space are Success by Sesame (Sesame’s clinician-led weight loss program) and Ro Body. At a high level, both platforms provide you with the same core things: access to FDA-approved medications, ongoing support, and prescription delivery to your door or preferred pharmacy.

Where they start to differ is price, medication options, and how quickly and personally your care is delivered. For patients paying out of pocket or trying to find a long-term plan they can stick with, these details can make a meaningful difference. This guide will give you a detailed comparison of both programs, so you can make the choice that’s best for you.

A quick disclaimer: this content is designed to help you compare options, not to offer medical advice or promote one program over another.

Ro vs Sesame online weight loss program similarities

At a clinical level, both Ro Body and Success by Sesame are designed to help patients lose weight safely using prescription medications and ongoing support.

For patients, this means that regardless of which platform you choose, you’ll have access to many of the same tools and safeguards that support effective, long-term weight loss, from medication management to progress tracking and lifestyle guidance. Here are some of the main similarities between Ro Body and Success by Sesame.

Comparable weight loss outcomes

Since providers on both programs can prescribe GLP-1 medications, patients can expect similar average weight loss results.

Side effect management and titration support

Both Ro and Sesame include unlimited messaging and app features to help manage common side effects of weight loss medication, such as nausea or fatigue. Providers on both platforms can also prescribe treatments to assist with these side effects, like ondansetron for nausea. This support and guidance is an important part of taking your medication safely and comfortably, especially during the first few months of treatment.

Progress tracking tools and monitoring

Each program includes app-based tools for tracking weight changes, logging doses, and monitoring your weight loss progress over time. These features can help patients stay consistent and informed throughout treatment.

Nutrition and lifestyle guidance

Both platforms provide guidance around diet, nutrition, and healthy habits to support medication-based weight loss.

With Success by Sesame, this guidance is delivered by your dedicated provider, who oversees both prescribing and ongoing care. With Ro, nutrition and lifestyle support may come from an assigned health coach, who is not always the same clinician who prescribes your medication.

Virtual visits and messaging

Both memberships include video visits and unlimited provider messaging, which helps keep care continuous rather than limited to scheduled check-ins. This can be especially helpful during dose adjustments or early in treatment, when questions and side effects are more common.

Medication insurance support

If you have health insurance and are trying to get coverage for your GLP-1 medication, providers on both platforms will offer assistance with prior authorization paperwork.

If your insurance doesn’t cover your medication, your Ro Body or Success by Sesame provider can also work with your insurance to try and get another medication covered. They can also recommend lower-cost self-pay medication options if you do not have insurance coverage.

HSA/FSA-eligible care

With both Success by Sesame and the Ro Body program, your monthly care and medications qualify for HSA and FSA reimbursement. This means you can use your tax-exempt dollars to pay for these programs, which can help save you money in the long run.

Ro vs Sesame online weight loss program differences

While your weight loss outcomes will likely be pretty similar with both Sesame and Ro, there are a few important differences between these two programs when it comes to affordability, medication options, and several other factors.

Lower monthly care cost

Success by Sesame’s monthly care fee starts at $99/mo, with some clinicians charging slightly more since clinicians on Sesame set their own prices. However, you’ll be able to see prices before you book, so you’ll always know what you’re paying.

Ro’s monthly membership fee is $145 per month, with a $100 discount for the first month. That’s $46 more per month than Sesame. For patients paying out of pocket, monthly care fees add up quickly, especially since weight loss treatment is often a long-term commitment, and weight loss medications can be expensive without insurance coverage.

A wider range of medication options

One of the biggest differences is the range of medications available to each patient. Ro’s weight loss program offers access to a focused set of GLP-1 options: Wegovy® (injection and oral pill), Zepbound® (pen and vial), and Ozempic®. For patients who know they want one of these medications, this simplicity can be appealing.

Success by Sesame offers access to all of the medications that Ro offers, plus additional injectable and oral options, such as:

• Rybelsus® (oral GLP-1)
• Liraglutide (Saxenda)
• Liraglutide (Victoza)
• Generic liraglutide
• Metformin
• Bupropion/naltrexone (Contrave®)
• Topiramate (Topamax®)
• Orlistat (Xenical®)

While not all of these medications are FDA-approved specifically for weight loss, each has been shown to support weight loss and may be prescribed off label if a Sesame provider believes it’s a good fit for your health history.

Not everyone tolerates GLP-1 injections well, and some patients prefer oral medications or need a lower-cost option long term. A broader menu gives providers more ways to tailor treatment — especially if side effects, supply issues, or budget become concerns.

Care experience and speed

The Success by Sesame program features hundreds of providers with same-day availability for your initial weight loss video consult. This live video visit allows for real-time discussion before a prescription is written, and it also means that your provider can write a same-day prescription if it’s right for you.

With Ro, most care begins with an online intake that’s reviewed asynchronously by a clinician. Patients are typically notified within a couple of days whether they’re eligible for medication, and prescriptions are often written without a live video visit unless your state requires it.

If you want to ask questions, discuss options live, or get started quickly, Sesame’s weight loss program may be a better option. Ro’s asynchronous care may appeal to those who prefer a more hands-off process.

Which online weight loss program is right for you, Ro or Sesame?

Both Ro and Success by Sesame offer evidence-based weight loss care using proven medications.

Ro may appeal to patients who are ok with a higher monthly membership fee, prefer a largely asynchronous experience, and already know they want a specific GLP-1 medication offered within Ro’s program.

Success by Sesame may be a better fit for patients who want lower monthly care costs, faster access to care, and a more personalized, ongoing relationship with a dedicated provider. With transparent pricing, same-day video visits, and a broader range of medication options — including both GLP-1s and lower-priced non-GLP-1 options — Sesame offers more flexibility for patients paying out of pocket or managing long-term treatment.